TALK OF THE NATION: Almost as soon as it was introduced in 1987, the antidepressant Prozac, which selectively targets the chemical serotonin, became a blockbuster. “Prozac just blew everything else out of the water,” Frazer says. This had less to do with the efficacy of Prozac (it is not better at treating depression than tricyclics, the earlier generation of antidepressants) than with the fact that the drug had relatively few side effects. “It was very free of side effects,” says Pedro Delgado. “And so it began to be used very widely, and there was a lot of enthusiasm for it.” […]